IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma

Hiroki Hosoi; Shotaro Tabata; Hideki Kosako; Yoshikazu Hori; Tadashi Okamura; Yusuke Yamashita; Kota Fujimoto; Daiki Kajioka; Kentaro Suzuki; Motomi Osato; Gen Yamada; Takashi Sonoki

Leukemia Research Reports (Jan 2024)

IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma

Hiroki Hosoi,
Shotaro Tabata,
Hideki Kosako,
Yoshikazu Hori,
Tadashi Okamura,
Yusuke Yamashita,
Kota Fujimoto,
Daiki Kajioka,
Kentaro Suzuki,
Motomi Osato,
Gen Yamada,
Takashi Sonoki

Affiliations

Hiroki Hosoi: Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan
Shotaro Tabata: Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan
Hideki Kosako: Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan
Yoshikazu Hori: Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan
Tadashi Okamura: Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan
Yusuke Yamashita: Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan
Kota Fujimoto: Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
Daiki Kajioka: Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
Kentaro Suzuki: Faculty of Life and Environmental Sciences, University of Yamanashi, Takeda 4-4-37, Kofu City, Yamanashi, Japan
Motomi Osato: International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
Gen Yamada: Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
Takashi Sonoki: Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan; Corresponding author.

Journal volume & issue: Vol. 21
p. 100451

Abstract

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IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with Cλ1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words)

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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