Emerging Pathway to a Precision Medicine Approach for Angina With Nonobstructive Coronary Arteries in Women

Nisha Hosadurg, MD; Kelsey Watts, PhD; Shuo Wang, MD; Kelly E. Wingerter, MD; Angela M. Taylor, MD; Todd C. Villines, MD; Amit R. Patel, MD; Jamieson M. Bourque, MD; Jonathan R. Lindner, MD; Christopher M. Kramer, MD; Garima Sharma, MD; Patricia F. Rodriguez Lozano, MD

JACC: Advances (Aug 2024)

Emerging Pathway to a Precision Medicine Approach for Angina With Nonobstructive Coronary Arteries in Women

Nisha Hosadurg, MD,
Kelsey Watts, PhD,
Shuo Wang, MD,
Kelly E. Wingerter, MD,
Angela M. Taylor, MD,
Todd C. Villines, MD,
Amit R. Patel, MD,
Jamieson M. Bourque, MD,
Jonathan R. Lindner, MD,
Christopher M. Kramer, MD,
Garima Sharma, MD,
Patricia F. Rodriguez Lozano, MD

Affiliations

Nisha Hosadurg, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Kelsey Watts, PhD: Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Shuo Wang, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Kelly E. Wingerter, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Angela M. Taylor, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Todd C. Villines, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Amit R. Patel, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Jamieson M. Bourque, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Jonathan R. Lindner, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
Christopher M. Kramer, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA; Department of Radiology and Medical Imaging, University of Virginia Health, Charlottesville, Virginia, USA
Garima Sharma, MD: INOVA Heart and Vascular Institute, Fairfax, Virginia, USA
Patricia F. Rodriguez Lozano, MD: Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA; Department of Radiology and Medical Imaging, University of Virginia Health, Charlottesville, Virginia, USA; Address for correspondence: Dr Patricia Rodriguez Lozano, University of Virginia Health, 1215 Lee St., Box 800158, Charlottesville, Virginia 22908, USA.

Journal volume & issue: Vol. 3, no. 8
p. 101074

Abstract

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Women are disproportionately affected by symptoms of angina with nonobstructive coronary arteries (ANOCA) which is associated with significant mortality and economic impact. Although distinct endotypes of ANOCA have been defined, it is underdiagnosed and is often incompletely characterized when identified. Patients are often unresponsive to traditional therapeutic options, which are typically antianginal, and the current ability to guide treatment modification by specific pathways is limited. Studies have associated specific genetic loci, transcriptomic features, and biomarkers with ANOCA. Such panomic data, in combination with known imaging and invasive diagnostic techniques, should be utilized to define more precise pathophysiologic subtypes of ANOCA in women, which will in turn help to identify targeted, effective therapies. A precision medicine-based approach to managing ANOCA incorporating these techniques in women has the potential to significantly improve their clinical care.

Published in JACC: Advances

ISSN: 2772-963X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system; Medicine: Internal medicine: Medical emergencies. Critical care. Intensive care. First aid
Website: https://www.sciencedirect.com/journal/jacc-advances

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Abstract

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