Long COVID elevated MMP-9 and release from microglia by SARS-CoV-2 Spike protein

Kempuraj Duraisamy; Tsilioni Irene; Aenlle Kristina K.; Klimas Nancy G.; Theoharides Theoharis C.

doi:10.1515/tnsci-2022-0352

Translational Neuroscience (Oct 2024)

Long COVID elevated MMP-9 and release from microglia by SARS-CoV-2 Spike protein

Kempuraj Duraisamy,
Tsilioni Irene,
Aenlle Kristina K.,
Klimas Nancy G.,
Theoharides Theoharis C.

Affiliations

Kempuraj Duraisamy: Institute for Neuro-Immune Medicine (INIM), Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, 33328, United States of America
Tsilioni Irene: Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, 02111, United States of America
Aenlle Kristina K.: Institute for Neuro-Immune Medicine (INIM), Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, 33328, United States of America
Klimas Nancy G.: Institute for Neuro-Immune Medicine (INIM), Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, 33328, United States of America
Theoharides Theoharis C.: Institute for Neuro-Immune Medicine (INIM), Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, 33328, United States of America

DOI: https://doi.org/10.1515/tnsci-2022-0352
Journal volume & issue: Vol. 15, no. 1
pp. 577 – 9

Abstract

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Long COVID is a major health concern because many patients develop chronic neuropsychiatric symptoms, but the precise pathogenesis is unknown. Matrix metalloproteinase-9 (MMP-9) can disrupt neuronal connectivity and be elevated in patients with long COVID.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

About the journal

Abstract

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