Nature Communications (Feb 2023)

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

  • Shan Yao,
  • Min-Dong Xu,
  • Ying Wang,
  • Shen-Ting Zhao,
  • Jin Wang,
  • Gui-Fu Chen,
  • Wen-Bing Chen,
  • Jian Liu,
  • Guo-Bin Huang,
  • Wen-Juan Sun,
  • Yan-Yan Zhang,
  • Huan-Li Hou,
  • Lei Li,
  • Xiang-Dong Sun

DOI
https://doi.org/10.1038/s41467-023-36209-5
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 18

Abstract

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The role of glycolysis in depression is unclear. Here the authors report a glycolytic deficit under social stress and demonstrate that astrocytic LDHA affects neuronal excitability and depressive-like behaviours via lactate homeostasis in mice.