RUDN Journal of Medicine (Dec 2010)
The influence of chemical analogs of decarboxylated ornithine and S-(adenosil)-methionine on the growth of L-cell tissue culture
Abstract
The effect of aliphatic amino- and oxy-derivatives of Ornithine and of S-(Adenosil)-methionine on the growth of L-cells in tissue culture was studied. The common known specific inhibitors of polyamines synthesis enzymes DFMO and MGBG were used for control and monitoring of test compounds action efficiency. The action of 1-aminooxy-3-aminopropan (APA), S-(5'-desoxyadenosile)-S-methyl-β-thioethyl-hydroxylamine (AMA) individually manner and in combination of one with another was similar with DFMO and MGBG effect but less pronounced. The degree of L-cell growth inhibition in the 4th day achieved 50-60%. By the 7th day there was observed a tendency not only to the growth rate stabilization but also to its reconstruction. It is indicative of reversible effect of APA and AMA compounds action on the cell growth that it differs from DFMO and MGBG actions.
