Frontiers in Immunology (Feb 2024)
Multiple influence of immune cells in the bone metastatic cancer microenvironment on tumors
- Shixin Chen,
- Shixin Chen,
- Shixin Chen,
- Shixin Chen,
- Jiangchu Lei,
- Jiangchu Lei,
- Jiangchu Lei,
- Jiangchu Lei,
- Haochen Mou,
- Haochen Mou,
- Haochen Mou,
- Haochen Mou,
- Wenkan Zhang,
- Wenkan Zhang,
- Wenkan Zhang,
- Wenkan Zhang,
- Lingxiao Jin,
- Lingxiao Jin,
- Lingxiao Jin,
- Lingxiao Jin,
- Senxu Lu,
- Senxu Lu,
- Senxu Lu,
- Senxu Lu,
- Eloy Yinwang,
- Eloy Yinwang,
- Eloy Yinwang,
- Eloy Yinwang,
- Yucheng Xue,
- Yucheng Xue,
- Yucheng Xue,
- Yucheng Xue,
- Zhenxuan Shao,
- Zhenxuan Shao,
- Zhenxuan Shao,
- Zhenxuan Shao,
- Tao Chen,
- Tao Chen,
- Tao Chen,
- Tao Chen,
- Fangqian Wang,
- Fangqian Wang,
- Fangqian Wang,
- Fangqian Wang,
- Shenzhi Zhao,
- Shenzhi Zhao,
- Shenzhi Zhao,
- Shenzhi Zhao,
- Xupeng Chai,
- Xupeng Chai,
- Xupeng Chai,
- Xupeng Chai,
- Zenan Wang,
- Zenan Wang,
- Zenan Wang,
- Zenan Wang,
- Jiahao Zhang,
- Jiahao Zhang,
- Jiahao Zhang,
- Jiahao Zhang,
- Zengjie Zhang,
- Zengjie Zhang,
- Zengjie Zhang,
- Zengjie Zhang,
- Zhaoming Ye,
- Zhaoming Ye,
- Zhaoming Ye,
- Zhaoming Ye,
- Binghao Li,
- Binghao Li,
- Binghao Li,
- Binghao Li
Affiliations
- Shixin Chen
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Shixin Chen
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Shixin Chen
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Shixin Chen
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Jiangchu Lei
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Jiangchu Lei
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Jiangchu Lei
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Jiangchu Lei
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Haochen Mou
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Haochen Mou
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Haochen Mou
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Haochen Mou
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Wenkan Zhang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Wenkan Zhang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Wenkan Zhang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Wenkan Zhang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Lingxiao Jin
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Lingxiao Jin
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Lingxiao Jin
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Lingxiao Jin
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Senxu Lu
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Senxu Lu
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Senxu Lu
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Senxu Lu
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Eloy Yinwang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Eloy Yinwang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Eloy Yinwang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Eloy Yinwang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Yucheng Xue
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Yucheng Xue
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Yucheng Xue
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Yucheng Xue
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Zhenxuan Shao
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Zhenxuan Shao
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Zhenxuan Shao
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Zhenxuan Shao
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Tao Chen
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Tao Chen
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Tao Chen
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Tao Chen
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Fangqian Wang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Fangqian Wang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Fangqian Wang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Fangqian Wang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Shenzhi Zhao
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Shenzhi Zhao
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Shenzhi Zhao
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Shenzhi Zhao
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Xupeng Chai
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Xupeng Chai
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Xupeng Chai
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Xupeng Chai
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Zenan Wang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Zenan Wang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Zenan Wang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Zenan Wang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Jiahao Zhang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Jiahao Zhang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Jiahao Zhang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Jiahao Zhang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Zengjie Zhang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Zengjie Zhang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Zengjie Zhang
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Zengjie Zhang
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Zhaoming Ye
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Zhaoming Ye
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Zhaoming Ye
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Zhaoming Ye
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- Binghao Li
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Binghao Li
- Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China
- Binghao Li
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China
- Binghao Li
- Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang, China
- DOI
- https://doi.org/10.3389/fimmu.2024.1335366
- Journal volume & issue
-
Vol. 15
Abstract
Bone is a common organ for solid tumor metastasis. Malignant bone tumor becomes insensitive to systemic therapy after colonization, followed by poor prognosis and high relapse rate. Immune and bone cells in situ constitute a unique immune microenvironment, which plays a crucial role in the context of bone metastasis. This review firstly focuses on lymphatic cells in bone metastatic cancer, including their function in tumor dissemination, invasion, growth and possible cytotoxicity-induced eradication. Subsequently, we examine myeloid cells, namely macrophages, myeloid-derived suppressor cells, dendritic cells, and megakaryocytes, evaluating their interaction with cytotoxic T lymphocytes and contribution to bone metastasis. As important components of skeletal tissue, osteoclasts and osteoblasts derived from bone marrow stromal cells, engaging in ‘vicious cycle’ accelerate osteolytic bone metastasis. We also explain the concept tumor dormancy and investigate underlying role of immune microenvironment on it. Additionally, a thorough review of emerging treatments for bone metastatic malignancy in clinical research, especially immunotherapy, is presented, indicating current challenges and opportunities in research and development of bone metastasis therapies.
Keywords
- bone metastatic cancer
- tumor immune microenvironment
- TME
- immune cell
- immunosuppression
- metastasizing
