The temporal expression patterns of brain transcriptome during chicken development and ageing

Zhongxian Xu; Tiandong Che; Feng Li; Kai Tian; Qing Zhu; Shailendra Kumar Mishra; Yifei Dai; Mingzhou Li; Diyan Li

doi:10.1186/s12864-018-5301-x

BMC Genomics (Dec 2018)

The temporal expression patterns of brain transcriptome during chicken development and ageing

Zhongxian Xu,
Tiandong Che,
Feng Li,
Kai Tian,
Qing Zhu,
Shailendra Kumar Mishra,
Yifei Dai,
Mingzhou Li,
Diyan Li

Affiliations

Zhongxian Xu: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
Tiandong Che: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
Feng Li: Key Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), China West Normal University
Kai Tian: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
Qing Zhu: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
Shailendra Kumar Mishra: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
Yifei Dai: Novogene Bioinformatics Institute
Mingzhou Li: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
Diyan Li: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University

DOI: https://doi.org/10.1186/s12864-018-5301-x
Journal volume & issue: Vol. 19, no. 1
pp. 1 – 12

Abstract

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Abstract Background The transcriptional profiles of mammals during brain development and ageing have been characterized. However the global expression patterns of transcriptome in the chicken brain have not been explored. Here, we systematically investigated the temporal expression profiles of lncRNAs and mRNAs across 8 stages (including 3 embryonic stages, 2 growth stages and 3 adult stages) in the female chicken cerebrum. Results We identified 39,907 putative lncRNAs and 14,558 mRNAs, investigated the temporal expression patterns by tracking a set of age-dependent genes and predicted potential biological functions of lncRNAs based on co-expression network. The results showed that genes with functions in development, synapses and axons exhibited a progressive decay; genes related to immune response were up-regulated with age. Conclusions These results may reflect changes in the regulation of transcriptional networks and provide non-coding RNA gene candidates for further studies and would contribute to a comprehensive understanding of the molecular mechanisms of chicken development and may provide insights or deeper understanding regarding the regulatory mechanisms of age-dependent protein coding and non-protein coding genes in chicken. In addition, as the chicken is an important model organism bridging the evolutionary gap between mammals and other vertebrates, these high resolution data may provide a novel evidence to improve our comprehensive understanding of the brain transcriptome during vertebrate evolution.

Published in BMC Genomics

ISSN: 1471-2164 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Biology (General): Genetics
Website: http://bmcgenomics.biomedcentral.com

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