SMIM1 at a glance; discovery, genetic basis, recent progress and perspectives

Yaw Aniweh; Prince B. Nyarko; Evelyn Quansah; Laty Gaye Thiam; Gordon A. Awandare

Parasite Epidemiology and Control (May 2019)

SMIM1 at a glance; discovery, genetic basis, recent progress and perspectives

Yaw Aniweh,
Prince B. Nyarko,
Evelyn Quansah,
Laty Gaye Thiam,
Gordon A. Awandare

Affiliations

Yaw Aniweh: West Africa Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana; Corresponding author.
Prince B. Nyarko: West Africa Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana; Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana
Evelyn Quansah: West Africa Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana; Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana
Laty Gaye Thiam: West Africa Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana; Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana
Gordon A. Awandare: West Africa Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana; Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana

Journal volume & issue: Vol. 5

Abstract

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Recent elucidation of the genetic basis of the Vel blood group system has offered the field of blood transfusion medicine an additional consideration in determining the causes of hemolytic reactions after a patient is transfused. The identification of the SMIM1 gene to be responsible for the Vel blood group allows molecular based tools to be developed to further dissect the function of this antigen. Genetic signatures such as the homozygous 17 bp deletion and the heterozygous 17 bp deletion in combination with other single nucleotide polymorphisms (SNPs) and insertion sequences regulate the expression level of the gene. With this knowledge, it is now possible to study this antigen in-depth. Keywords: Vel, Blood, Nucleotides, Frameshift, Heterozygous

Published in Parasite Epidemiology and Control

ISSN: 2405-6731 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.journals.elsevier.com/parasite-epidemiology-and-control/

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