Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Aug 2009)
Effects of Teucrium Polium Honey on Burn Wound Healing Process
Abstract
BACKGROUND AND OBJECTIVE: Wound healing, care promotion, appropriate treatment and infection and chronicity prevention have all been occupied the human mind. The aim of the present study was to evaluate the effect of Teucrium polium honey on the burn wound healing process in rat.METHODS: The present experimental study accomplished on 28 rats (weight 200-250 g). Animals were divided into two control and Teucrium polium honey groups. In each group, 6 rats used for wound healing assessment and 8 for histopathological test. Burn wound was created by hot metal, 1×1 cm2, on the back. Gentamycin (5 mg/kg ip) was injected in two groups. In case group, Teucrium polium honey (1 g/day) was applied on wounds twice a day until complete healing was obtained. Evaluation was made through measuring the area of the healed region and tensiometery experiments.FINDINGS: The percentage of wound healing on days 12 and 18 in control group of burn wounds changed in the treated group from 30.2% and 61.4% to 39% and 78% (p<0.05), respectively. Stress (maximum tensile force causing skin rupture) changed from 5.3±0.64 Newton in the control group of burn wounds to 6.6±0.65 Newton in treated group with no significant difference. Strain (tissue length under maximum strain) changed from 13.6±1.2 mm in the control burn wound group to 18±2.1 mm (p<0.05) in the treated group. In point of view of histopathology examinations, healing process was better achieved in the treated group with more oriented matrix arrangement and less inflammatory reaction than control group.CONCLUSION: Our findings suggest that Teucrium polium honey may have accelerated the burn wound healing in rats.
