Cancers (Jul 2021)
Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset
- Caroline Himbert,
- Jane C. Figueiredo,
- David Shibata,
- Jennifer Ose,
- Tengda Lin,
- Lyen C. Huang,
- Anita R. Peoples,
- Courtney L. Scaife,
- Bartley Pickron,
- Laura Lambert,
- Jessica N. Cohan,
- Mary Bronner,
- Seth Felder,
- Julian Sanchez,
- Sophie Dessureault,
- Domenico Coppola,
- David M. Hoffman,
- Yosef F. Nasseri,
- Robert W. Decker,
- Karen Zaghiyan,
- Zuri A. Murrell,
- Andrew Hendifar,
- Jun Gong,
- Eiman Firoozmand,
- Alexandra Gangi,
- Beth A. Moore,
- Kyle G. Cologne,
- Maryliza S. El-Masry,
- Nathan Hinkle,
- Justin Monroe,
- Matthew Mutch,
- Cory Bernadt,
- Deyali Chatterjee,
- Mika Sinanan,
- Stacey A. Cohen,
- Ulrike Wallin,
- William M. Grady,
- Paul D. Lampe,
- Deepti Reddi,
- Mukta Krane,
- Alessandro Fichera,
- Ravi Moonka,
- Esther Herpel,
- Peter Schirmacher,
- Matthias Kloor,
- Magnus von Knebel-Doeberitz,
- Johanna Nattenmueller,
- Hans-Ulrich Kauczor,
- Eric Swanson,
- Jolanta Jedrzkiewicz,
- Stephanie L. Schmit,
- Biljana Gigic,
- Alexis B. Ulrich,
- Adetunji T. Toriola,
- Erin M. Siegel,
- Christopher I. Li,
- Cornelia M. Ulrich,
- Sheetal Hardikar
Affiliations
- Caroline Himbert
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Jane C. Figueiredo
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- David Shibata
- Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 37996, USA
- Jennifer Ose
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Tengda Lin
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Lyen C. Huang
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Anita R. Peoples
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Courtney L. Scaife
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Bartley Pickron
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Laura Lambert
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Jessica N. Cohan
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Mary Bronner
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Seth Felder
- H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- Julian Sanchez
- H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- Sophie Dessureault
- H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- Domenico Coppola
- H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- David M. Hoffman
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Yosef F. Nasseri
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Robert W. Decker
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Karen Zaghiyan
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Zuri A. Murrell
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Andrew Hendifar
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Jun Gong
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Eiman Firoozmand
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Alexandra Gangi
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Beth A. Moore
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Kyle G. Cologne
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Maryliza S. El-Masry
- Cedars-Sinai Center, Los Angeles, CA 90048, USA
- Nathan Hinkle
- Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 37996, USA
- Justin Monroe
- Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 37996, USA
- Matthew Mutch
- Department of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA
- Cory Bernadt
- Department of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA
- Deyali Chatterjee
- Department of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA
- Mika Sinanan
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Stacey A. Cohen
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Ulrike Wallin
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- William M. Grady
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Paul D. Lampe
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Deepti Reddi
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Mukta Krane
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Alessandro Fichera
- Baylor Scott & White Health, Dallas, TX 76712, USA
- Ravi Moonka
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Esther Herpel
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Peter Schirmacher
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Matthias Kloor
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Magnus von Knebel-Doeberitz
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Johanna Nattenmueller
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Hans-Ulrich Kauczor
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Eric Swanson
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Jolanta Jedrzkiewicz
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Stephanie L. Schmit
- H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- Biljana Gigic
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Alexis B. Ulrich
- Pathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany
- Adetunji T. Toriola
- Department of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA
- Erin M. Siegel
- H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- Christopher I. Li
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Cornelia M. Ulrich
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- Sheetal Hardikar
- Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
- DOI
- https://doi.org/10.3390/cancers13153817
- Journal volume & issue
-
Vol. 13,
no. 15
p. 3817
Abstract
Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (n = 2193). We calculated descriptive statistics and assessed associations of clinicodemographic factors with age of onset using mutually-adjusted logistic regression models. Patients were on average 60 years old, with BMI of 29 kg/m2, 52% colon cancers, 21% early-onset, and presented with stage II or III (60%) disease. Early-onset patients presented with more advanced disease (stages III–IV: 63% vs. 51%, respectively), and received more neo and adjuvant treatment compared to late-onset patients, after controlling for stage (odds ratio (OR) (95% confidence interval (CI)) = 2.30 (1.82–3.83) and 2.00 (1.43–2.81), respectively). Early-onset rectal cancer patients across all stages more commonly received neoadjuvant treatment, even when not indicated as the standard of care, e.g., during stage I disease. The odds of early-onset disease were higher among never smokers and lower among overweight patients (1.55 (1.21–1.98) and 0.56 (0.41–0.76), respectively). Patients with early-onset colorectal cancer were more likely to be diagnosed with advanced stage disease, to have received systemic treatments regardless of stage at diagnosis, and were less likely to be ever smokers or overweight.
Keywords
