Pathogenetic mechanisms of neurologycal post COVID syndrome and the basis of its pathogenetic treatment and prevention (literature review)

Abstract

The neurological manifestations in the post COVID period are identified about 34 % of surviving patients. Currently, the term “neurological post COVID syndrome” is proposed, which includes the functional or organic brain disorders after the survived COVID infection. The presence of neurological complications after COVID gave the beginning of research on studying the impact of this viral infection on neurons. However, the total pathophysiological mechanism of nerve cells disorders remains understandable only partially and requires additional research and clarification. In the article such the probable factors of the neurological post-person syndrome pathogenesis, as chronic hypoxia, the pathological immune response, the direct damaging action of the virus and the neurotropism of immune complexes, the endothelial dysfunction of the brain vessels, the state of the intestinal microbiota and the complication of therapy used for the treatment of acute SARSCOV- 2 are discussed. In accordance with these mechanisms, recommendations on the pathogenetic treatment and prevention of neurological post COVID syndrome are given.

Keywords

• neurological post covid syndrome
• covid-19
• neurotropism
• endothelial dysfunction
• pathological immune response
• microbiota