Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel

Jonathan Mount; Grigory Maksaev; Brock T. Summers; James A. J. Fitzpatrick; Peng Yuan

doi:10.1038/s41467-022-34737-0

Nature Communications (Nov 2022)

Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel

Jonathan Mount,
Grigory Maksaev,
Brock T. Summers,
James A. J. Fitzpatrick,
Peng Yuan

Affiliations

Jonathan Mount: Department of Cell Biology and Physiology, Washington University School of Medicine
Grigory Maksaev: Department of Cell Biology and Physiology, Washington University School of Medicine
Brock T. Summers: Washington University Center for Cellular Imaging, Washington University School of Medicine
James A. J. Fitzpatrick: Department of Cell Biology and Physiology, Washington University School of Medicine
Peng Yuan: Department of Cell Biology and Physiology, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-34737-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Mechanosensitive ion channels mediate biological force sensation, but the underlying mechanism remains poorly understood. Here, authors present the structural basis of mechanotransduction in an ion channel revealed by cryo-electron microscopy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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