Nature Communications (Dec 2019)
Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
- Tomoyuki Tsukiyama,
- Kenichi Kobayashi,
- Masataka Nakaya,
- Chizuru Iwatani,
- Yasunari Seita,
- Hideaki Tsuchiya,
- Jun Matsushita,
- Kahoru Kitajima,
- Ikuo Kawamoto,
- Takahiro Nakagawa,
- Koji Fukuda,
- Teppei Iwakiri,
- Hiroyuki Izumi,
- Iori Itagaki,
- Shinji Kume,
- Hiroshi Maegawa,
- Ryuichi Nishinakamura,
- Saori Nishio,
- Shinichiro Nakamura,
- Akihiro Kawauchi,
- Masatsugu Ema
Affiliations
- Tomoyuki Tsukiyama
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Kenichi Kobayashi
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Masataka Nakaya
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Chizuru Iwatani
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Yasunari Seita
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Hideaki Tsuchiya
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Jun Matsushita
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Kahoru Kitajima
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Ikuo Kawamoto
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Takahiro Nakagawa
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Koji Fukuda
- Shin Nippon Biomedical Laboratories, Ltd
- Teppei Iwakiri
- Shin Nippon Biomedical Laboratories, Ltd
- Hiroyuki Izumi
- Shin Nippon Biomedical Laboratories, Ltd
- Iori Itagaki
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Shinji Kume
- Department of Medicine, Shiga University of Medical Science
- Hiroshi Maegawa
- Department of Medicine, Shiga University of Medical Science
- Ryuichi Nishinakamura
- Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
- Saori Nishio
- Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine
- Shinichiro Nakamura
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- Akihiro Kawauchi
- Department of Urology, Shiga University of Medical Science
- Masatsugu Ema
- Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
- DOI
- https://doi.org/10.1038/s41467-019-13398-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting these may provide insights into ADPKD pathogenesis and contribute to the development of future therapeutic strategies.
