Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma

Hiroki Ishii; Takahiro Tsujikawa; Naoki Oishi; Arisa Kinouchi; Kaname Sakamoto; Junichi Mitsuda; Hiroshi Ogi; Kyoko Itoh; Tetsuo Kondo; Shigeru Hirano; Daiju Sakurai

doi:10.1002/ccr3.6050

Clinical Case Reports (Jul 2022)

Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma

Hiroki Ishii,
Takahiro Tsujikawa,
Naoki Oishi,
Arisa Kinouchi,
Kaname Sakamoto,
Junichi Mitsuda,
Hiroshi Ogi,
Kyoko Itoh,
Tetsuo Kondo,
Shigeru Hirano,
Daiju Sakurai

Affiliations

Hiroki Ishii: Department of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan
Takahiro Tsujikawa: Department of Otolaryngology‐Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan
Naoki Oishi: Department of pathology, Interdisciplinary Graduate School of Medicine University of Yamanashi Chuo Japan
Arisa Kinouchi: Department of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan
Kaname Sakamoto: Department of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan
Junichi Mitsuda: Department of Otolaryngology‐Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan
Hiroshi Ogi: Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine Kyoto Japan
Kyoko Itoh: Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine Kyoto Japan
Tetsuo Kondo: Department of pathology, Interdisciplinary Graduate School of Medicine University of Yamanashi Chuo Japan
Shigeru Hirano: Department of Otolaryngology‐Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan
Daiju Sakurai: Department of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan

DOI: https://doi.org/10.1002/ccr3.6050
Journal volume & issue: Vol. 10, no. 7
pp. n/a – n/a

Abstract

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Abstract Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD‐1/PD‐L1 pathway, possibly strengthening the rationale for immune checkpoint blockade as a novel treatment.

Published in Clinical Case Reports

ISSN: 2050-0904 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://onlinelibrary.wiley.com/journal/20500904

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Abstract

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