The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats

Roshan-Milani S.; Khalilpour J.; Fard A. Abdollahzade

doi:10.2478/amb-2019-0017

Acta Medica Bulgarica (May 2019)

The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats

Roshan-Milani S.,
Khalilpour J.,
Fard A. Abdollahzade

Affiliations

Roshan-Milani S.: Departments of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, − Urmia, Iran
Khalilpour J.: Departments of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, − Urmia, Iran
Fard A. Abdollahzade: Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, − Urmia, Iran

DOI: https://doi.org/10.2478/amb-2019-0017
Journal volume & issue: Vol. 46, no. 2
pp. 41 – 46

Abstract

Read online

Background/objectives: Recent data suggest a role for heparanase in several proteinuric conditions. An increased glomerular heparanase expression is associated with loss of heparan sulfate in the glomerular basement membrane (GBM). The aim of the present study was to investigate the renal effects of heparanase inhibition in a diabetic experimental model.

Published in Acta Medica Bulgarica

ISSN: 0324-1750 (Print); 2719-5384 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine
Website: https://sciendo.com/journal/AMB

About the journal

Abstract

Keywords