The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis

Hongyu Shen; Xun Huang; Yiheng Zhao; Dongmei Wu; Kaili Xue; Jingfei Yao; Yushuang Wang; Nan Tang; Yifu Qiu

doi:10.1038/s41467-022-33800-0

Nature Communications (Oct 2022)

The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis

Hongyu Shen,
Xun Huang,
Yiheng Zhao,
Dongmei Wu,
Kaili Xue,
Jingfei Yao,
Yushuang Wang,
Nan Tang,
Yifu Qiu

Affiliations

Hongyu Shen: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University
Xun Huang: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University
Yiheng Zhao: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University
Dongmei Wu: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University
Kaili Xue: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University
Jingfei Yao: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University
Yushuang Wang: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University
Nan Tang: National Institute of Biological Sciences
Yifu Qiu: Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University

DOI: https://doi.org/10.1038/s41467-022-33800-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Adipose tissue fibrosis is connected to obesity-related metabolic dysfunction. Qiu and colleagues discover that the Hippo pathway acts as a molecular switch in the initiation and development of adipose tissue fibrosis upon TGFβ stimulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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