Status for clinically complete remission rectal cancer after concomitant chemo-radiotherapy in Taiwan

Geng-Ping Lin; Kuan-Der Lee; Jeng-Yi Wang; Jinn-Shiun Chen; Chun-Ju Chiang; Chien-Yuh Yeh

Asian Journal of Surgery (May 2018)

Status for clinically complete remission rectal cancer after concomitant chemo-radiotherapy in Taiwan

Geng-Ping Lin,
Kuan-Der Lee,
Jeng-Yi Wang,
Jinn-Shiun Chen,
Chun-Ju Chiang,
Chien-Yuh Yeh

Affiliations

Geng-Ping Lin: Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan
Kuan-Der Lee: Department of Hematology and Oncology, Taipei Medical University Hospital, Taipei, Taiwan
Jeng-Yi Wang: Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Clinical Medical Sciences, Chang-Gung University, Taoyuan, Taiwan
Jinn-Shiun Chen: Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Clinical Medical Sciences, Chang-Gung University, Taoyuan, Taiwan
Chun-Ju Chiang: Graduate Institution of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Taiwan Cancer Registry, Taipei, Taiwan
Chien-Yuh Yeh: Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Clinical Medical Sciences, Chang-Gung University, Taoyuan, Taiwan; Corresponding author. Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, No. 5, Fu-Hsing Street, Kuei Shan District, Taoyuan City, Taiwan. Fax: +886 3 327 8355.

Journal volume & issue: Vol. 41, no. 3
pp. 203 – 209

Abstract

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Summary: Treatment for Rectal cancer changed after the induction of concomitant chemo-radiotherapy, CCRT. Complete remission of the tumor leads to debate of the necessity of surgical intervention. We evaluate the treatment outcome to know if operation is beneficial to these patients. Patients received long course concomitant chemo-radiotherapy for advanced rectal cancer between 2004 and 2013 in Taiwan were enrolled. Total 2780 patients diagnosed advanced rectal cancer were enrolled. In these patients, 2578 received surgical intervention and 202 were in wait and see for complete remission tumor. Higher local recurrence rate was found with wait and see group (8.9% vs. 2.7%). Also, better overall survival, disease free survival and local recurrence free survival were seen with the surgical intervention group. Surgical intervention may be benefit for some misdiagnosed completed response to CCRT. Keywords: Rectal cancer, Complete remission, Long course CCRT, Watch and wait

Published in Asian Journal of Surgery

ISSN: 1015-9584 (Print)
Publisher: Elsevier
Country of publisher: Hong Kong
LCC subjects: Medicine: Surgery
Website: http://www.journals.elsevier.com/asian-journal-of-surgery/

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