Protective Effect of Zataria Multiflora Boiss against Cisplatin-Induced Hematotoxicity in Mice

Abstract

Background and purpose: Cisplatin (CP) is an anticancer drug that cause hematological changes. Zataria Multiflora Boiss (ZM) has antioxidant property. The preset study was done to determine the protective effect of ZM against hematological changes induced by Cisplatin in mice. Materials and methods: Thirty two adult male mice (25-30 g) were divided into 4 groups: the control group received normal saline for 7 days; ZM group received ZM (200 mg/kg) for 7 days by gavage; CP group received Intraperitoneal CP (10 mg/kg) injection at day 5; ZM + CP group received ZM for 7 days and CP was injected at day 5. Then, blood samples were taken for hematological assessment at day 8 of the study. Data were analyzed by SPSS applying ANOVA and Tukey test. Results: The number of red blood cells, hemoglobin levels, platelets, MCV, MCH, and MCHC significantly decreased and white blood cells increased in the group that received CP compared with those of the control group. ZM improved these changes (P<0.05). Conclusion: ZM improved hematological changes induced by Cisplatin in mice.

Keywords

• cisplatin
• zataria multiflora boiss
• hematological parameters