Communications Biology (Nov 2022)
Angiopoietin-like 2 is essential to aortic valve development in mice
- Pauline Labbé,
- Victoria Munoz Goyette,
- Nathalie Thorin-Trescases,
- Louis Villeneuve,
- Ines Desanlis,
- Constance Delwarde,
- Yan-Fen Shi,
- Cécile Martel,
- Carol Yu,
- Azadeh Alikashani,
- Maya Mamarbachi,
- Frédéric Lesage,
- Samuel Mathieu,
- Jean-Claude Tardif,
- Patrick Mathieu,
- Marie Kmita,
- Éric Thorin
Affiliations
- Pauline Labbé
- Montreal Heart Institute, Université de Montréal
- Victoria Munoz Goyette
- Montreal Heart Institute, Université de Montréal
- Nathalie Thorin-Trescases
- Montreal Heart Institute, Université de Montréal
- Louis Villeneuve
- Montreal Heart Institute, Université de Montréal
- Ines Desanlis
- Faculty of Medicine, Department of Medicine, Université de Montréal, Montreal Clinical Research Institute
- Constance Delwarde
- Université de Nantes, CNRS, INSERM, l’institut du thorax
- Yan-Fen Shi
- Montreal Heart Institute, Université de Montréal
- Cécile Martel
- Montreal Heart Institute, Université de Montréal
- Carol Yu
- Montreal Heart Institute, Université de Montréal
- Azadeh Alikashani
- Montreal Heart Institute, Université de Montréal
- Maya Mamarbachi
- Montreal Heart Institute, Université de Montréal
- Frédéric Lesage
- Montreal Heart Institute, Université de Montréal
- Samuel Mathieu
- Faculty of Medicine, Department of Surgery, Université Laval
- Jean-Claude Tardif
- Montreal Heart Institute, Université de Montréal
- Patrick Mathieu
- Faculty of Medicine, Department of Surgery, Université Laval
- Marie Kmita
- Faculty of Medicine, Department of Medicine, Université de Montréal, Montreal Clinical Research Institute
- Éric Thorin
- Montreal Heart Institute, Université de Montréal
- DOI
- https://doi.org/10.1038/s42003-022-04243-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 18
Abstract
Mice knockdown for Angiopoietin-like 2 (Angptl2) exhibit spontaneous aortic valve stenosis associated with a decrease in Notch signalling and an imbalance in cell apoptosis, senescence and proliferation during embryonic valve remodelling stage.
