Cross-Neutralization between Human and African Bat Mumps Viruses

Abstract

Recently, a new paramyxovirus closely related to human mumps virus (MuV) was detected in bats. We generated recombinant MuVs carrying either or both of the fusion and hemagglutinin-neuraminidase bat virus glycoproteins. These viruses showed replication kinetics similar to human MuV in cultured cells and were neutralized efficiently by serum from healthy humans.

Keywords

• bat virus
• Chimeric virus
• mumps virus
• African bat mumps virus
• neutralization
• viruses