PGC1 alpha coactivates ERG fusion to drive antioxidant target genes under metabolic stress

Aiindrila Dhara; Imlimaong Aier; Ankush Paladhi; Pritish Kumar Varadwaj; Sumit Kumar Hira; Nirmalya Sen

doi:10.1038/s42003-022-03385-x

Communications Biology (May 2022)

PGC1 alpha coactivates ERG fusion to drive antioxidant target genes under metabolic stress

Aiindrila Dhara,
Imlimaong Aier,
Ankush Paladhi,
Pritish Kumar Varadwaj,
Sumit Kumar Hira,
Nirmalya Sen

Affiliations

Aiindrila Dhara: Molecular oncology laboratory, S.N. Bose innovation centre, University of Kalyani
Imlimaong Aier: Department of Bioinformatics & Applied Sciences, Indian Institute of Information Technology—
Ankush Paladhi: Cellular Immunology Laboratory, Department of Zoology, The University of Burdwan
Pritish Kumar Varadwaj: Department of Bioinformatics & Applied Sciences, Indian Institute of Information Technology—
Sumit Kumar Hira: Cellular Immunology Laboratory, Department of Zoology, The University of Burdwan
Nirmalya Sen: Molecular oncology laboratory, S.N. Bose innovation centre, University of Kalyani

DOI: https://doi.org/10.1038/s42003-022-03385-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

Read online

PGC1α acts as a co-activator of the ERG transcription factor during metabolic stress resulting in antioxidant functionsand inhibition of the PGC1α-ERG driven transcriptional program reduces prostate cancer growth by inducing ROS mediated apoptosis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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