Trametinib inhibits RAS-mutant MLL-rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo

• Mark Kerstjens,
• Sandra S. Pinhancos,
• Patricia Garrido Castro,
• Pauline Schneider,
• Priscilla Wander,
• Rob Pieters,
• Ronald W. Stam

Affiliations

Mark Kerstjens

Pediatric Oncology/Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands

Sandra S. Pinhancos

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands

Patricia Garrido Castro

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands

Pauline Schneider

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands

Priscilla Wander

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands

Rob Pieters

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands

Ronald W. Stam

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands