Study of the lipid status and indicators of hemostasis among young men of different ethnic groups to assess thrombogenic risk

Abstract

The aim of the study was to investigate the lipid status and indicators of the system of hemostasis in healthy young men of different linguistic families of the North Caucasus region to assess the risk of development of thrombogenic states.. Material and methods. A survey of young men aged 18 to 21 years was carried out with the subsequent establishment of region of residence and nationality to form ethnic groups. Based on the information received during the survey, 62 people were selected: 32 young men of the Indo-European language family (Russians, Greeks, Armenians) and 30 young men of the North Caucasian language family (Chechens, Ingush, Avars, Dargins). The assessment of lipid status was carried out by the photocolorimetric method on a biochemical analyzer, and the analysis of indicators of the hemostasis system was carried out by the clotting method on an automatic coagulometer analyzer. Homocysteine levels were determined by chemiluminescent immunoassay on a microplate device. Genetic polymorphisms of the hemostatic system were identified using the real-time PCR. Results. Young men of the Indo-European language family have significantly more low density lipoprotein, triglyceride, homocysteine and antithrombine III content, than representatives of the North Caucasian language family (p < 0.001), and less total number and average platelet volume, prothrombin index, prothrombin concentration according to Quick (p < 0.001). There was also a significantly more frequent occurrence of mutations of the gene encoding fibrinase (p < 0.05) in young men of the Indo-European language family. Conclusions. A comprehensive study among young men of different ethnicities illustrates ethnic differences in lipid status and homocysteine level. Analysis of the main indicators of coagulogram and genetic polymorphism of the hemostasis system allowed us to establish a higher risk of thrombogenic conditions and atherosclerosis in young men of the North Caucasian language family

Keywords

• lipid profile
• homocysteine
• coagulation profile
• genetic polymorphism of the hemostatic system
• ethnicity