Journal of Microbiology, Immunology and Infection (Jun 2021)

CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

  • Gilbert Aaron Lee,
  • Nan-Shih Liao

Journal volume & issue
Vol. 54, no. 3
pp. 514 – 517

Abstract

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The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

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