Lipids in Health and Disease (Aug 2011)

Relationship between lipid profiles and plasma total homocysteine, cysteine and the risk of coronary artery disease in coronary angiographic subjects

  • Ling Wenhua,
  • Qiu Jian,
  • Xia Min,
  • Li Dan,
  • Su Dongfang,
  • Lv Xiaofei,
  • Zhang Yuan,
  • Xiao Yunjun,
  • Ma Jing

DOI
https://doi.org/10.1186/1476-511X-10-137
Journal volume & issue
Vol. 10, no. 1
p. 137

Abstract

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Abstract Background Homocysteine and cysteine are considered as risk factors of cardiovascular disease. Homocysteine influences the liver expression of ApoA-I and decreases its blood level and HDL in genetic mice model. We aimed therefore to evaluate whether homocysteine and cysteine are associated with lipid parameters, and the joint effects of them on the risk of coronary artery disease (CAD). Plasma total homocysteine (tHcy), cysteine (tCys) and lipid markers were measured in 2058 consecutive coronary artery angiographic patients. Results Plasma tHcy but not tCys correlated negatively with ApoA-I (r = -0.153, P P Conclusions The association of homocysteine and cysteine, ApoA-I or HDL cholesterol and their joint effects provide new insights on its role on CAD.

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