Diagnostics (Sep 2021)

Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group

  • Diego Santos García,
  • Teresa de Deus Fonticoba,
  • Carlos Cores Bartolomé,
  • Lucía Naya Ríos,
  • Lucía García Roca,
  • Cristina Martínez Miró,
  • Hector Canfield,
  • Silvia Jesús,
  • Miquel Aguilar,
  • Pau Pastor,
  • Marina Cosgaya,
  • Juan García Caldentey,
  • Nuria Caballol,
  • Inés Legarda,
  • Jorge Hernández Vara,
  • Iria Cabo,
  • Lydia López Manzanares,
  • Isabel González Aramburu,
  • María A. Ávila Rivera,
  • Víctor Gómez Mayordomo,
  • Víctor Nogueira,
  • Víctor Puente,
  • Julio Dotor,
  • Carmen Borrué,
  • Berta Solano Vila,
  • María Álvarez Sauco,
  • Lydia Vela,
  • Sonia Escalante,
  • Esther Cubo,
  • Francisco Carrillo Padilla,
  • Juan C. Martínez Castrillo,
  • Pilar Sánchez Alonso,
  • Maria G. Alonso Losada,
  • Nuria López Ariztegui,
  • Itziar Gastón,
  • Jaime Kulisevsky,
  • Marta Blázquez Estrada,
  • Manuel Seijo,
  • Javier Rúiz Martínez,
  • Caridad Valero,
  • Mónica Kurtis,
  • Oriol de Fábregues,
  • Jessica González Ardura,
  • Ruben Alonso Redondo,
  • Carlos Ordás,
  • Luis M. López Díaz,
  • Darrian McAfee,
  • Pablo Martinez-Martin,
  • Pablo Mir,
  • COPPADIS Study Group

DOI
https://doi.org/10.3390/diagnostics11101801
Journal volume & issue
Vol. 11, no. 10
p. 1801

Abstract

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Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.

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