VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS

Abstract

Purpose: studying of endotoxin antibodies level of classes G, M, A and level of C-reactive protein at patients on a programhemodialysis and a constant peritoneal dialysis.Materials and methods:16 patients with a chronic kidneys disease 5 stage on a peritoneal dialysis and 62 patients on a program hemodialysis are surveyed. Level endotoxin antibody classes G, M, A, and C-reactive protein was determined by ELISA.Results: it is established that patients on a peritonial dialysis have level anti-ET-IgG in 4.9 times in comparison with group of conditionally healthy patients, and levels anti-ET-IgA and anti-ET-IgM didn’t differ from norm indicators. Also increase of level of C-reactive protein in 8.8 times, in comparison with indicators of healthy donors. At patients on a program hemodialysis increase in 5.6 times anti-ET-IgG, and in 8 times of C-reactive protein in comparison with group of healthy patients. And levels anti-ET-IgA and anti-ET-IgM also didn’t differ from norm indicators. Levels of endotoxin antibodies and C-reactive protein at patients on a hemodialysis and on a peritonial dialysis among didn’t differ.Conclusion: in both groups of patients found an increased antibody response to ET (on a high level of anti-ET-IgG) against the background of a high level of systemic inflammation (at the level of C-reactive protein). There is chronic endotoxin aggression in hemodialysis patients.

Keywords

• chronic kidney disease
• dialysis
• chronic inflammation
• endotoxin
• endotoxin immunity