Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

Masao Kakoki; Purushotham V. Ramanathan; John R. Hagaman; Ruriko Grant; Jennifer C. Wilder; Joan M. Taylor; J. Charles Jennette; Oliver Smithies; Nobuyo Maeda-Smithies

doi:10.1038/s42003-021-02291-y

Communications Biology (Jun 2021)

Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

Masao Kakoki,
Purushotham V. Ramanathan,
John R. Hagaman,
Ruriko Grant,
Jennifer C. Wilder,
Joan M. Taylor,
J. Charles Jennette,
Oliver Smithies,
Nobuyo Maeda-Smithies

Affiliations

Masao Kakoki: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Purushotham V. Ramanathan: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
John R. Hagaman: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Ruriko Grant: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Jennifer C. Wilder: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Joan M. Taylor: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
J. Charles Jennette: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Oliver Smithies: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Nobuyo Maeda-Smithies: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s42003-021-02291-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Kakoki et al report a role for cyanocobalamin (B12) in preventing cardiomyopathy in type 1 diabetic mice, by reducing levels of reactive oxygen species and restoring IGF-1 levels via DNMT-SOCS1/3 signalling. The authors therefore propose B12 as a promising option to prevent diabetic cardiomyopathy through its cardioprotective effects.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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