Nature Communications (Sep 2017)
Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
- Ya-Kun Zhang,
- Yuan-Yuan Qu,
- Yan Lin,
- Xiao-Hui Wu,
- Hou-Zao Chen,
- Xu Wang,
- Kai-Qiang Zhou,
- Yun Wei,
- Fushen Guo,
- Cui-Fang Yao,
- Xia-Di He,
- Li-Xia Liu,
- Chen Yang,
- Zong-Yuan Guan,
- Shi-Dong Wang,
- Jianyuan Zhao,
- De-Pei Liu,
- Shi-Min Zhao,
- Wei Xu
Affiliations
- Ya-Kun Zhang
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Yuan-Yuan Qu
- Department of Urology, Fudan University Shanghai Cancer Center
- Yan Lin
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Xiao-Hui Wu
- Institute of Developmental Biology and Molecular Medicine, Fudan University
- Hou-Zao Chen
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
- Xu Wang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
- Kai-Qiang Zhou
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Yun Wei
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Fushen Guo
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Cui-Fang Yao
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Xia-Di He
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Li-Xia Liu
- Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Chen Yang
- Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Zong-Yuan Guan
- Sophie Davis School of Biomedical Education, City University of New York Medical School
- Shi-Dong Wang
- Vanderbilt University School of Medicine
- Jianyuan Zhao
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- De-Pei Liu
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
- Shi-Min Zhao
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- Wei Xu
- Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life Sciences
- DOI
- https://doi.org/10.1038/s41467-017-00489-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.
