Nature Communications (Sep 2022)

Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity

  • Martin J. Scurr,
  • George Lippiatt,
  • Lorenzo Capitani,
  • Kirsten Bentley,
  • Sarah N. Lauder,
  • Kathryn Smart,
  • Michelle S. Somerville,
  • Tara Rees,
  • Richard J. Stanton,
  • Awen Gallimore,
  • James P. Hindley,
  • Andrew Godkin

DOI
https://doi.org/10.1038/s41467-022-32985-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

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The presence of SARS-CoV-2-specific antibodies alone is not an accurate determinant of immunity. In this work, the authors investigate if whole-blood based measurement of SARS-CoV-2 specific T cell responses could prognosticate the risk of possible SARS-CoV-2 infection, and recapitulate their findings in a capillary blood-based assay.