PACAP suppresses dry eye signs by stimulating tear secretion

Tomoya Nakamachi; Hirokazu Ohtaki; Tamotsu Seki; Sachiko Yofu; Nobuyuki Kagami; Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba; Laszlo Mark; Ingela Lanekoff; Peter Kiss; Jozsef Farkas; Dora Reglodi; Seiji Shioda

doi:10.1038/ncomms12034

Nature Communications (Jun 2016)

PACAP suppresses dry eye signs by stimulating tear secretion

Tomoya Nakamachi,
Hirokazu Ohtaki,
Tamotsu Seki,
Sachiko Yofu,
Nobuyuki Kagami,
Hitoshi Hashimoto,
Norihito Shintani,
Akemichi Baba,
Laszlo Mark,
Ingela Lanekoff,
Peter Kiss,
Jozsef Farkas,
Dora Reglodi,
Seiji Shioda

Affiliations

Tomoya Nakamachi: Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama
Hirokazu Ohtaki: Department of Anatomy, Showa University School of Medicine
Tamotsu Seki: Department of Anatomy, Showa University School of Medicine
Sachiko Yofu: Department of Anatomy, Showa University School of Medicine
Nobuyuki Kagami: Department of Anatomy, Showa University School of Medicine
Hitoshi Hashimoto: Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
Norihito Shintani: Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
Akemichi Baba: Hyogo University of Health Sciences
Laszlo Mark: Department of Analytical Biochemistry, Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs
Ingela Lanekoff: Department of Chemistry-BMC, Uppsala University
Peter Kiss: Department of Anatomy, MTA-PTE PACAP Lendulet Research Group, Centre for Neuroscience, University of Pécs
Jozsef Farkas: Department of Anatomy, Showa University School of Medicine
Dora Reglodi: Department of Anatomy, MTA-PTE PACAP Lendulet Research Group, Centre for Neuroscience, University of Pécs
Seiji Shioda: Innovative Drug Discovery, Global Research Center for Innovative Life Science, Hoshi University

DOI: https://doi.org/10.1038/ncomms12034
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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