The WDR11 complex facilitates the tethering of AP-1-derived vesicles

Paloma Navarro Negredo; James R. Edgar; Paul T. Manna; Robin Antrobus; Margaret S. Robinson

doi:10.1038/s41467-018-02919-4

Nature Communications (Feb 2018)

The WDR11 complex facilitates the tethering of AP-1-derived vesicles

Paloma Navarro Negredo,
James R. Edgar,
Paul T. Manna,
Robin Antrobus,
Margaret S. Robinson

Affiliations

Paloma Navarro Negredo: Cambridge Institute for Medical Research, University of Cambridge
James R. Edgar: Cambridge Institute for Medical Research, University of Cambridge
Paul T. Manna: Cambridge Institute for Medical Research, University of Cambridge
Robin Antrobus: Cambridge Institute for Medical Research, University of Cambridge
Margaret S. Robinson: Cambridge Institute for Medical Research, University of Cambridge

DOI: https://doi.org/10.1038/s41467-018-02919-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Trafficking from endosomes to the trans-Golgi network requires recognition of vesicle tethers during membrane docking. Here, the authors identify a complex localised to AP-1 generated vesicles containing WDR11, C17orf75 and FAM91A, which together with TBC1D23 facilitates vesicle capture on Golgi membranes

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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