Nature Communications (Mar 2016)

Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells

  • Ayumu Suzuki,
  • Masataka Hirasaki,
  • Tomoaki Hishida,
  • Jun Wu,
  • Daiji Okamura,
  • Atsushi Ueda,
  • Masazumi Nishimoto,
  • Yutaka Nakachi,
  • Yosuke Mizuno,
  • Yasushi Okazaki,
  • Yasuhisa Matsui,
  • Juan Carlos Izpisua Belmonte,
  • Akihiko Okuda

DOI
https://doi.org/10.1038/ncomms11056
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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The mechanisms that trigger meiosis in germ cells and halt this process in non-germline cells are unclear. Here, the authors show that knockout of Maxin embryonic stem cells results in meiotic onset in a mechanism that involves the PRC1 complex.