Revista Brasileira de Saúde Materno Infantil (Jan 2024)

Obstacles in combating multidrug resistant tuberculosis in pediatric patients: a scope review

  • Letícia Baltar Sobreira,
  • Paula de Souza Silva Freitas,
  • Luciana de Cassia Nunes Nascimento,
  • Anne Caroline Barbosa Cerqueira Vieira,
  • Carolina Maia Martins Sales,
  • Alicia de Oliveira Pacheco,
  • Lucas Dalvi Armond Rezende

DOI
https://doi.org/10.1590/1806-9304202400000082-en
Journal volume & issue
Vol. 24

Abstract

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Abstract Objectives: to identify the scientific evidence on excessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: “What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis in pediatric patients?”. The research used the descriptors: “extensively drug-resistant tuberculosis” OR “multidrug-resistant tuberculosis” AND “pediatrics”. The research was carried out in a double-blind manner in the following databases of the Medical Literature Analysis and Retrieval System Online, Regional Office for the Western Pacific’s Institutional Repository for Information Sharing, Embase/Elsevier and International Clinical Trials Registry Platform, with a temporal cut-off from 2011 to 2021, sending a final synthesized sample of 18 articles, which evaluated the methodological content through the level of evidence. Results: the results show the lack of research with a high level of evidence related to MDR-TB in children, the lack of adequate dosage of second-line drugs for the pediatric population and the importance of drug sensitivity testing for the cases of treatment Conclusions: it was identified that the obstacles to MDR-TB treatment were concentrated in the lack of detailed protocols, safe drug dosages with a low side effect, and mainly in the social health determinants and disease process involving MDR-TB.

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