Communications Biology (Dec 2021)
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
- Jianfeng Li,
- Silvia Garavaglia,
- Zhaofeng Ye,
- Andrea Moretti,
- Olga V. Belyaeva,
- Alison Beiser,
- Md Ibrahim,
- Anna Wilk,
- Steve McClellan,
- Alla V. Klyuyeva,
- Kelli R. Goggans,
- Natalia Y. Kedishvili,
- E. Alan Salter,
- Andrzej Wierzbicki,
- Marie E. Migaud,
- Steven J. Mullett,
- Nathan A. Yates,
- Carlos J. Camacho,
- Menico Rizzi,
- Robert W. Sobol
Affiliations
- Jianfeng Li
- Mitchell Cancer Institute, University of South Alabama
- Silvia Garavaglia
- Department of Pharmaceutical Sciences, University of Piemonte Orientale
- Zhaofeng Ye
- Department of Computational and Systems Biology, University of Pittsburgh
- Andrea Moretti
- Department of Pharmaceutical Sciences, University of Piemonte Orientale
- Olga V. Belyaeva
- Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry
- Alison Beiser
- Mitchell Cancer Institute, University of South Alabama
- Md Ibrahim
- Mitchell Cancer Institute, University of South Alabama
- Anna Wilk
- Mitchell Cancer Institute, University of South Alabama
- Steve McClellan
- Mitchell Cancer Institute, University of South Alabama
- Alla V. Klyuyeva
- Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry
- Kelli R. Goggans
- Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry
- Natalia Y. Kedishvili
- Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry
- E. Alan Salter
- Department of Chemistry, University of South Alabama
- Andrzej Wierzbicki
- Department of Chemistry, University of South Alabama
- Marie E. Migaud
- Mitchell Cancer Institute, University of South Alabama
- Steven J. Mullett
- Department of Cell Biology, University of Pittsburgh
- Nathan A. Yates
- Department of Cell Biology, University of Pittsburgh
- Carlos J. Camacho
- Department of Computational and Systems Biology, University of Pittsburgh
- Menico Rizzi
- Department of Pharmaceutical Sciences, University of Piemonte Orientale
- Robert W. Sobol
- Mitchell Cancer Institute, University of South Alabama
- DOI
- https://doi.org/10.1038/s42003-021-02949-7
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 16
Abstract
Using in silico modeling, Li et al. identify a selective inhibitor for aldehyde dehydrogenase isoform ALDH1A3, which is highly expressed in mesenchymal glioma stem cells and therefore a potential drug target. They solve the structure of the ALDH1A3/MCI-INI-3 inhibitor complex and find that the inhibitor is as efficient as ALDH1A3 depletion in preventing retinoic acid biosynthesis.
