ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Shaghayegh Nouruzi; Dwaipayan Ganguli; Nakisa Tabrizian; Maxim Kobelev; Olena Sivak; Takeshi Namekawa; Daksh Thaper; Sylvan C. Baca; Matthew L. Freedman; Adeleke Aguda; Alastair Davies; Amina Zoubeidi

doi:10.1038/s41467-022-29963-5

Nature Communications (Apr 2022)

ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Shaghayegh Nouruzi,
Dwaipayan Ganguli,
Nakisa Tabrizian,
Maxim Kobelev,
Olena Sivak,
Takeshi Namekawa,
Daksh Thaper,
Sylvan C. Baca,
Matthew L. Freedman,
Adeleke Aguda,
Alastair Davies,
Amina Zoubeidi

Affiliations

Shaghayegh Nouruzi: Department of Urologic Sciences, University of British Columbia
Dwaipayan Ganguli: Vancouver Prostate Centre
Nakisa Tabrizian: Department of Urologic Sciences, University of British Columbia
Maxim Kobelev: Department of Urologic Sciences, University of British Columbia
Olena Sivak: Vancouver Prostate Centre
Takeshi Namekawa: Department of Urologic Sciences, University of British Columbia
Daksh Thaper: Department of Urologic Sciences, University of British Columbia
Sylvan C. Baca: Departement of Medical Oncology, Dana-Farber Cancer Institute
Matthew L. Freedman: Departement of Medical Oncology, Dana-Farber Cancer Institute
Adeleke Aguda: Vancouver Prostate Centre
Alastair Davies: Department of Urologic Sciences, University of British Columbia
Amina Zoubeidi: Department of Urologic Sciences, University of British Columbia

DOI: https://doi.org/10.1038/s41467-022-29963-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Following androgen receptor pathway inhibition prostate cancers can differentiate towards the neuroendocrine lineage. Here, the authors identify epigenetic alterations regulated by ASCL1 and suggest targeting ASCL1 to reverse the neuroendocrine phenotype.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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