Nature Communications (Sep 2022)
Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling
- Sneha Mishra,
- Claudia Cosentino,
- Ankit Kumar Tamta,
- Danish Khan,
- Shalini Srinivasan,
- Venkatraman Ravi,
- Elena Abbotto,
- Bangalore Prabhashankar Arathi,
- Shweta Kumar,
- Aditi Jain,
- Anand S. Ramaian,
- Shruti M. Kizkekra,
- Raksha Rajagopal,
- Swathi Rao,
- Swati Krishna,
- Ninitha Asirvatham-Jeyaraj,
- Elizabeth R. Haggerty,
- Dafne M. Silberman,
- Irwin J. Kurland,
- Ravindra P. Veeranna,
- Tamilselvan Jayavelu,
- Santina Bruzzone,
- Raul Mostoslavsky,
- Nagalingam R. Sundaresan
Affiliations
- Sneha Mishra
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Claudia Cosentino
- The Massachusetts General Hospital Cancer Center, Harvard Medical School
- Ankit Kumar Tamta
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Danish Khan
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Shalini Srinivasan
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Venkatraman Ravi
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Elena Abbotto
- Department of Experimental Medicine, Section of Biochemistry, University of Genoa
- Bangalore Prabhashankar Arathi
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Shweta Kumar
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Aditi Jain
- Centre for BioSystems Science and Engineering, Indian Institute of Science
- Anand S. Ramaian
- Department of Biotechnology, Anna University
- Shruti M. Kizkekra
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Raksha Rajagopal
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Swathi Rao
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Swati Krishna
- Department of Microbiology and Cell Biology, Indian Institute of Science
- Ninitha Asirvatham-Jeyaraj
- Department of Biotechnology, Indian Institute of Technology
- Elizabeth R. Haggerty
- The Massachusetts General Hospital Cancer Center, Harvard Medical School
- Dafne M. Silberman
- Centro de Estudios Farmacologicos y Botanicos (CEFYBO-CONICET), Catedra de Farmacologia, Facultad de Medicina
- Irwin J. Kurland
- Albert Einstein College of Medicine
- Ravindra P. Veeranna
- Department of Biochemistry, CSIR- Central Food Technological Research Institute
- Tamilselvan Jayavelu
- Department of Biotechnology, Anna University
- Santina Bruzzone
- Department of Experimental Medicine, Section of Biochemistry, University of Genoa
- Raul Mostoslavsky
- The Massachusetts General Hospital Cancer Center, Harvard Medical School
- Nagalingam R. Sundaresan
- Department of Microbiology and Cell Biology, Indian Institute of Science
- DOI
- https://doi.org/10.1038/s41467-022-32905-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Chronic stress induces skeletal muscle atrophy via upregulation of glucocorticoid levels. Here, the authors show that SIRT6 transcriptionally regulates glucocorticoid-induced muscle atrophy by modulating IGF/PI3K/AKT signalling.
