The Influence of Sempervivum Tectorum and Melatonin Administration on Erythrocyte Catalase in Rats Exposed to Aluminium Sulphate

Abstract

The aim of the study was to highlight the effect of Sempervivum tectorum and melatonin administration in rats exposed to aluminium sulphate through drinking water on the erythrocyte catalase activity The researches were carried out on Wistar albinos rats, grouped in 8 lots: a control lot (C) and 7 experimental lots (E1: 10% Sempervivum tectorum aqueous extract, 3 month; E2: melatonin, 10 mg/100 ml water, 3 month; E3: aluminium sulphate, 3 months; E4: aluminium sulphate with 10% Sempervivum tectorum aqueous extract, 3 months; E5: aluminium sulphate with melatonin 3 months; E6: aluminium sulphate 3 months followed by 10% Sempervivum tectorum aqueous extract for a month; E7: aluminium sulphate 3 months, followed by melatonin for a month). Al(3+) level in drinking water was 1000 ppb. It was registered decrease of catalase activity compared to C group in E3, E4 (p0.05) and an insignificant increase in E1, E2, E6, E7 groups. Sempervivum tectorum and melatonin administration led to the increase of catalase activity comparing to the group exposed only to aluminium. The catalase activity increase was significantly higher in case of consecutive administration to aluminium intake. Melatonin effect was more well-marked as the one induced by Sempervivum tectorum (p>0.05).

Keywords

• aluminium
• catalase
• melatonin
• rat
• sempervivum tectorum