Медицинский совет (Sep 2018)

Evaluation of the effect of taurine on the course of coronary artery disease associated with diabetes of the 2nd type, in patients undergoing coronary revascularization

  • A. V. Svarovskaya,
  • A. A. Garganeeva

DOI
https://doi.org/10.21518/2079-701X-2018-16-94-99
Journal volume & issue
Vol. 0, no. 16
pp. 94 – 99

Abstract

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The aim was to study the effect of taurine in the complex therapy of patients with coronary artery disease associated with type 2 diabetes mellitus (DM2) who underwent coronary revascularization.Material and methods. Examined 53 patients with coronary artery disease associated with type 2 diabetes, after undergoing endovascular revascularization of the myocardium, which were distributed in 2 groups. The 1st group included 30 patients who received, in addition to basic therapy, taurine at a dose of 500 mg 2 times a day. In group 2 (n = 23) – patients who received only basic therapy of ischemic heart disease and diabetes. Body mass index, waist and hip volume, as well as physical tolerance by means of Bicycle ergometry and 6-minute walk test were evaluated. Indicators of carbohydrate and lipid metabolism wer e determined, insulin resistance index was calculated.Results. At the end of 16-week therapy, physical tolerance according toVEM in group 1 increased by 29.67% (p<0.01), in group 2-by 9.14% (p>0.05). The distance during the 6-minute walk test was significantly increased in both groups: by 34.37% and by 25.80%, respectively. Patients of group 1 had a significant decrease in BMI by 11.52%, postprandial glucose level by 19.38% (p = 0.018), insulin by 18.90%, glyca ted hemoglobin (HbA1c) by 13.21%, insulin resistance index by 17.65%, triglyceride by 14.14% (p<0.05), low density lipoprotein cholesterol by 16.05% (p<0.01).), aspartate aminotransferases and alanine aminotransferases – by 27.75% and 16.52%, respectively.Conclusion. Sup plement taurine standard therapy of coronary heart disease associated with type 2 diabetes mellitus, in patients who have undergone endovascular myocardial revascularization, has a positive effect on the performance of carbohydrate and lipid metabolism, reduces body weight, improves physical performance.

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