Annals of Pediatric Cardiology (Jan 2020)

Early experience with pediatric cardiac transplantation in a limited resource setting

  • Swati Garekar,
  • Talha Meeran,
  • Vinay Patel,
  • Sachin Patil,
  • Shyam Dhake,
  • Shivaji Mali,
  • Amit Mhatre,
  • Dilip Bind,
  • Ashish Gaur,
  • Sandeep Sinha,
  • Vijay Shetty,
  • Kirtis Sabnis,
  • Bharat Soni,
  • Dhananjay Malankar,
  • Anvay Mulay

DOI
https://doi.org/10.4103/apc.APC_105_19
Journal volume & issue
Vol. 13, no. 3
pp. 220 – 226

Abstract

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Background: Pediatric heart transplantation is a now a well-established and standard treatment option for end stage heart failure for various conditions in children. Due to logistic issues, it is not an option for in most pediatric cardiac centres in the third world. Aim: We sought to describe our early experience in the current era in India. Methods: This is a short term retrospective chart review of pediatric patients who underwent heart transplantation at our centre. Mean/Median with standard deviation /range was used to present data. Results: Twenty patients underwent orthotopic heart transplant between January 2016 and June 2019. The median age at transplant was 12.4years (range 3.3 to 17.3 years). The median weight was 23.2kg (range 10-80kg). The mean donor/recipient weight ratio was 1.62± 0.84. The mean ICU stay was 12.1days. The mean follow up post transplant was 2.03± 0.97years (range 10 days-3.57years). The 1 month and the 1 year survival was 100%. Biopsies were positive for significant rejection in 7 patients (35%). At the time of last follow-up, 3 patients (15%) had expired. The major post transplant morbidities were mechanical circulatory support (n=3), hypertension with seizure complex (n=3), post transplant lympho-proliferative disorder (n=1), pseudocyst of pancreas (n=1), coronary allograft vasculopathy (n=3) and systemic hypertension (n=7). All surviving patients (n=17) were asymptomatic at last follow up. Conclusion: The results suggest acceptable short term outcomes in Indian pediatric patients can be achieved after heart transplantation in the current era. Significant rejection episodes and coronary allograft vasculopathy need careful follow up.

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