Nature Communications (Feb 2019)
Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
- J. Mathieu,
- D. Detraux,
- D. Kuppers,
- Y. Wang,
- C. Cavanaugh,
- S. Sidhu,
- S. Levy,
- A. M. Robitaille,
- A. Ferreccio,
- T. Bottorff,
- A. McAlister,
- L. Somasundaram,
- F. Artoni,
- S. Battle,
- R. D. Hawkins,
- R. T. Moon,
- C. B. Ware,
- P. J. Paddison,
- H. Ruohola-Baker
Affiliations
- J. Mathieu
- Department of Biochemistry, University of Washington
- D. Detraux
- Department of Biochemistry, University of Washington
- D. Kuppers
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Y. Wang
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- C. Cavanaugh
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- S. Sidhu
- Department of Biochemistry, University of Washington
- S. Levy
- Department of Biochemistry, University of Washington
- A. M. Robitaille
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- A. Ferreccio
- Department of Biochemistry, University of Washington
- T. Bottorff
- Department of Biochemistry, University of Washington
- A. McAlister
- Department of Biochemistry, University of Washington
- L. Somasundaram
- Department of Biochemistry, University of Washington
- F. Artoni
- Department of Biochemistry, University of Washington
- S. Battle
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- R. D. Hawkins
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- R. T. Moon
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- C. B. Ware
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- P. J. Paddison
- Institute for Stem Cell and Regenerative Medicine, University of Washington
- H. Ruohola-Baker
- Department of Biochemistry, University of Washington
- DOI
- https://doi.org/10.1038/s41467-018-08020-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN) by regulating the mTOR and Wnt pathways.
