Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles

Alin Rai; David W. Greening; Rong Xu; Maoshan Chen; Wittaya Suwakulsiri; Richard J. Simpson

doi:10.1038/s42003-021-01882-z

Communications Biology (Mar 2021)

Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles

Alin Rai,
David W. Greening,
Rong Xu,
Maoshan Chen,
Wittaya Suwakulsiri,
Richard J. Simpson

Affiliations

Alin Rai: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe University
David W. Greening: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe University
Rong Xu: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe University
Maoshan Chen: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe University
Wittaya Suwakulsiri: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe University
Richard J. Simpson: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe University

DOI: https://doi.org/10.1038/s42003-021-01882-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Rai et al. characterise the properties of secreted midbody remnants, showing they are distinct from exosomes and microvesicles. The authors also find that these vesicles are engulfed by cells and promote anchorage independent growth and invasive phenotypes in NIH3T3 fibroblasts.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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