Journal of Cardiovascular Development and Disease (Feb 2023)

Association between Genetic Variants of <i>CELSR2-PSRC1-SORT1</i> and Cardiovascular Diseases: A Systematic Review and Meta-Analysis

  • Rosa Giannina Castillo-Avila,
  • Thelma Beatriz González-Castro,
  • Carlos Alfonso Tovilla-Zárate,
  • José Jaime Martínez-Magaña,
  • María Lilia López-Narváez,
  • Isela Esther Juárez-Rojop,
  • Pedro Iván Arias-Vázquez,
  • Verónica Marusa Borgonio-Cuadra,
  • Nonanzit Pérez-Hernández,
  • José Manuel Rodríguez-Pérez

DOI
https://doi.org/10.3390/jcdd10030091
Journal volume & issue
Vol. 10, no. 3
p. 91

Abstract

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A cluster of three genes CELSR2, PSRC1, and SORT1 has been associated with cardiovascular diseases. Thus, the aim of this study was (i) to perform a systematic review and updated meta-analysis of the association of three polymorphisms (rs646776, rs599839, and rs464218) of this cluster with cardiovascular diseases, and (ii) to explore by PheWAS signals of the three SNPs in cardiovascular diseases and to evaluate the effect of rs599839 with tissue expression by in silico tools. Three electronic databases were searched to identify eligible studies. The meta-analysis showed that the rs599839 (allelic OR 1.19, 95% CI 1.13–1.26, dominant OR 1.22, 95% CI 1.06–1.39, recessive OR 1.23, 95% CI 1.15–1.32), rs646776 (allelic OR 1.46, 95% CI 1.17–1.82) polymorphisms showed an increased risk for cardiovascular diseases. PheWas analysis showed associations with coronary artery disease and total cholesterol. Our results suggest a possible involvement of the CELSR2-PSRC1-SORT1 cluster variants in the risk association of cardiovascular diseases, particularly coronary artery disease.

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