Indian Pacing and Electrophysiology Journal (Nov 2009)

Omega-3 Polyunsaturated Fatty Acid Supplementation Reduced Atrial Fibrillation Recurrence after Pulmonary Vein Antrum Isolation

  • Dimpi Patel,
  • Mazen Shaheen,
  • Preeti Venkatraman,
  • Luciana Armaganijan,
  • Javier E Sanchez,
  • Rodney P Horton,
  • Luigi Di Biase,
  • Prasant Mohanty,
  • Robert Canby,
  • Robert Canby,
  • Shane M Bailey,
  • J David Burkhardt,
  • G Joesph Gallinghouse,
  • Jason D Zagrodzky,
  • Marketa Kozeluhova,
  • Andrea Natale

Journal volume & issue
Vol. 9, no. 6
pp. 292 – 298

Abstract

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Objective: To assess if patients treated with omega-3(n-3) polyunsaturated fatty acids (PUFAS) had lower procedural failure rates compared to an untreated population.Methods and Results: From January 2004 to 2007, 1500 PVAI patients underwent catheter ablation. Two hundred and eighty five (19%) patients were treated with PUFAs. These patients were matched in a nested case controlled analysis. After matching, there were 129 patients in the PUFA group and 129 in the control group. Thirty-five (27.1%) patients in the study group had early recurrence vs. 57 (44.1%) in the control group p-value<0.0001. Twenty-nine (23.2%) patients in the PUFA group vs. 41 (31.7%) in the non-PUFA group had procedural failure (p-value <0.003). There were no significant differences in complications in the PUFA and non-PUFA groups.Conclusion: Patients treated with PUFAs had lower incidences of early recurrence and procedural failure compared to an untreated population.

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