Healing of Recurrent Aphthous Stomatitis by Non-Thermal Plasma: Pilot Study

Norma Guadalupe Ibáñez-Mancera; Régulo López-Callejas; Víctor Hugo Toral-Rizo; Benjamín Gonzalo Rodríguez-Méndez; Edith Lara-Carrillo; Rosendo Peña-Eguiluz; Regiane Cristina do Amaral; Antonio Mercado-Cabrera; Raúl Valencia-Alvarado

doi:10.3390/biomedicines11010167

Biomedicines (Jan 2023)

Healing of Recurrent Aphthous Stomatitis by Non-Thermal Plasma: Pilot Study

Norma Guadalupe Ibáñez-Mancera,
Régulo López-Callejas,
Víctor Hugo Toral-Rizo,
Benjamín Gonzalo Rodríguez-Méndez,
Edith Lara-Carrillo,
Rosendo Peña-Eguiluz,
Regiane Cristina do Amaral,
Antonio Mercado-Cabrera,
Raúl Valencia-Alvarado

Affiliations

Norma Guadalupe Ibáñez-Mancera: Interdisciplinary Center for Health Sciences CICS-UST, Instituto Politécnico Nacional, Av. Luis Enrique Erro S/N, Unidad Profesional Adolfo López Mateos, Zacatenco 07738, Mexico
Régulo López-Callejas: Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Víctor Hugo Toral-Rizo: Orocenter Clinic, Facultad de Odontología, Universidad Autónoma del Estado de México, Av. Paseo Tollocan esq. Jesús Carranza, Colonia Universidad, Toluca de Lerdo 50130, Mexico
Benjamín Gonzalo Rodríguez-Méndez: Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Edith Lara-Carrillo: Orocenter Clinic, Facultad de Odontología, Universidad Autónoma del Estado de México, Av. Paseo Tollocan esq. Jesús Carranza, Colonia Universidad, Toluca de Lerdo 50130, Mexico
Rosendo Peña-Eguiluz: Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Regiane Cristina do Amaral: Departamento de Odontología, Universidade Federal de Sergipe, Aracajú 49060-108, SE, Brazil
Antonio Mercado-Cabrera: Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Raúl Valencia-Alvarado: Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico

DOI: https://doi.org/10.3390/biomedicines11010167
Journal volume & issue: Vol. 11, no. 1
p. 167

Abstract

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Recurrent aphthous stomatitis (RAS) is a common disease in the oral cavity characterized by recurrent ulcers (RU). Usually, these cause acute pain without definitive treatment. The present study determines the efficacy of non-thermal plasma (NTP) for treating RU. NTP is applied to the patient’s RU using a radiofrequency generator connected to a point reactor. The power density applied to the ulcer is 0.50 W/cm2, less than 4 W/cm2, which is the maximum value without biological risk. Each patient received two treatments of three minutes each and spaced 60 min apart at a distance of 5 mm from the RU. From a sample of 30 ulcers in patients treated for RU with an average age of 37 years, they stated that the pain decreased considerably and without the need for ingestion of analgesics and antibiotics. Regeneration took place in an average of three days. The NTP proved to be an excellent therapeutic alternative for the treatment of RU since it has a rapid effect of reducing pain and inflammation, as well as adequate tissue regeneration.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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