Decrease of Serum AST, ALT, and GGT among Male Alcohol Drinkers with Coffee Consumption Habit.

Abstract

Summary: Background: Alcohol is the most important causes of liver cirrhosis. Many of the factors underlying the development of alcoholic liver diseases remain unknown. Recently, some epidemiological studies showed beneficial effects of coffee against the occurrence of alcoholic liver cirrhosis and upon serum liver enzymes level. These observations have been examined in this work. Patients and Methods: The relation of coffee drinking to serum GGT, AST and ALT activities were examined in 59 alcoholic male patients with or without habit of coffee consumption. 35 (59.3%) out of 59 patients were alcoholic drinkers without coffee consumption habit, and 24(40.7%) were alcohol drinkers with coffee consumption. In addition to 24 healthy persons as a control group. Results: Highly significant decrease in GGT (p<0.001), AST (p<0.001) and ALT (p<0.001) activities were found in alcoholic patients with coffee consumption habit as compared with alcoholic patients or with healthy control group. Conclusion: The result of this research suggested that coffee consumption may inhibit the induction of GGT in the liver by alcohol consumption, and may possibly protect against liver cell damage due to alcohol.

Keywords

• AST, ALT, GGT, Alcoholic, liver cirrhosis, coffee consumption.