Detection of novel transcripts and evaluation of expression levels of Igf2 in mouse placenta

Abstract

The imprinted Igf2 gene (Insulin-like growth factor 2) encodes a growth factor that plays an important role in the formation of the placenta and embryonic development. This study results showed that several new transcripts of the Igf2 gene were detected in the placenta of mice, and the new promoter in the placenta P0L and PU2 were found. Expression levels of these promoters as well as of the Igf2 gene were evaluated in the placentas of mice. The expression levels of these two promoters were investigated in different tissues; P0L is very well expressed in the brain and is clearly expressed in the placenta, tongue, and kidney; P0 is well expressed in the placenta, but also in the kidney and heart; PU2 is expressed in addition to the placenta, tongue, and muscles.