Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

Zhen-Dong Xiao; Leng Han; Hyemin Lee; Li Zhuang; Yilei Zhang; Joelle Baddour; Deepak Nagrath; Christopher G. Wood; Jian Gu; Xifeng Wu; Han Liang; Boyi Gan

doi:10.1038/s41467-017-00902-z

Nature Communications (Oct 2017)

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

Zhen-Dong Xiao,
Leng Han,
Hyemin Lee,
Li Zhuang,
Yilei Zhang,
Joelle Baddour,
Deepak Nagrath,
Christopher G. Wood,
Jian Gu,
Xifeng Wu,
Han Liang,
Boyi Gan

Affiliations

Zhen-Dong Xiao: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Leng Han: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
Hyemin Lee: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Li Zhuang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Yilei Zhang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Joelle Baddour: Department of Chemical and Biomolecular Engineering, Rice University
Deepak Nagrath: Department of Biomedical Engineering, University of Michigan
Christopher G. Wood: Department of Urology, The University of Texas MD Anderson Cancer Center
Jian Gu: Department of Epidemiology, The University of Texas MD Anderson Cancer Center
Xifeng Wu: Department of Epidemiology, The University of Texas MD Anderson Cancer Center
Han Liang: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
Boyi Gan: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-017-00902-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer (RCC). Here, the authors show that upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic rewiring.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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