Nature Communications (May 2017)

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

  • Olena Kis,
  • Rayan Kaedbey,
  • Signy Chow,
  • Arnavaz Danesh,
  • Mark Dowar,
  • Tiantian Li,
  • Zhihua Li,
  • Jessica Liu,
  • Mark Mansour,
  • Esther Masih-Khan,
  • Tong Zhang,
  • Scott V. Bratman,
  • Amit M. Oza,
  • Suzanne Kamel-Reid,
  • Suzanne Trudel,
  • Trevor J. Pugh

DOI
https://doi.org/10.1038/ncomms15086
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.