Nature Communications (May 2018)

MxB is an interferon-induced restriction factor of human herpesviruses

  • Michel Crameri,
  • Michael Bauer,
  • Nicole Caduff,
  • Raphael Walker,
  • Fiona Steiner,
  • Francesca D. Franzoso,
  • Cornelia Gujer,
  • Karin Boucke,
  • Talissa Kucera,
  • Andrea Zbinden,
  • Christian Münz,
  • Cornel Fraefel,
  • Urs F. Greber,
  • Jovan Pavlovic

DOI
https://doi.org/10.1038/s41467-018-04379-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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MxB is an interferon-induced GTPase that inhibits HIV replication. Here, Crameri et al. show that MxB restricts replication of herpesviruses by inhibiting delivery of incoming viral DNA into the nucleus, and this antiviral activity depends on MxB’s GTPase activity.